Hepatic Glucose 6 Phosphate Dehydrogenase (G6PD) plays a pivotal role in the Pentose Phosphate Pathway, generating NADPH for antioxidant defense and supporting nucleotide & amino acid biosynthesis. Glucose 6 phosphate dehydrogenase (G6PD): Response of the human erythrocyte and another cells to the decrease in their activity The Multiple Roles of Glucose 6 Phosphate Dehydrogenase in Tumorigenesis and Cancer Chemoresistance G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No