What is glutathione? Know as the most important antioxidant in the body, glutathione is an essential antioxidant manufactured in all cells, but primarily in the liver. It is essential because it Downregulation of Glutathione Biosynthesis Contributes to Oxidative Stress and Liver Dysfunction in Acute Kidney Injury Shang 2016 Oxidative Medicine and Cellular Longevity Wiley Online Library Glutathione in liver diseases and hepatotoxicity. Semantic Scholar Figure 2 from Glutathione synthesis. Semantic Scholar