As a precursor to make glutathione, NAC has been used for decades both as an acute medication and as an over the counter supplement. Recently, the line between medication and supplement has been All About NAC (N acetylcysteine): What it is and what benefits it has Zenement Is It Safe to Take Glutathione and Collagen Together? Exploring the Evidence of N Acetyl Cysteine (NAC) for Mood Disorders Psychopharmacology Institute